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Proceedings Paper

Optical tomography of a 3D multilayered head model
Author(s): Hamid Dehghani; Elizabeth M. C. Hillman; Martin Schweiger; Simon Robert Arridge; David T. Delpy
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Paper Abstract

The head is inherently a heterogenous 3 dimensional (3D) domain and any useful image reconstruction algorithm in optical tomography should be based on the true shape and dimensions of the domain to be imaged. However due to the computational complexity of the problem, most reconstruction algorithms have been based on either 2 dimensional (2D) domains or simple 3D homogenous models. In this work we use a complex multi-layered model of the head to generate data in the presence of known changes of absorption within the brain. In order to evaluate the reconstruction of images from 3D data, we use either a 2D mesh based on the outline of a single measurement plane, or a 3D mesh based on the forward model itself. We show that the use of a 2D model for the reconstruction of images from a complex heterogenous 3D model is not successful for absolute imaging of internal optical property. In 3D, image reconstruction using meantime data only from a 3D domain is not successful when reconstructing for absorption only while keeping background scatter constant and homogenous. Image reconstruction in 3D is greatly improved when a-priori structural knowledge is used. Reconstruction of internal absorption only, from difference data (data after a change in absorption minus data before a change) works both in 2D and 3D, however in 2D, any depth information available from the data is lost.

Paper Details

Date Published: 29 June 2001
PDF: 8 pages
Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); doi: 10.1117/12.434515
Show Author Affiliations
Hamid Dehghani, Univ. College London (United States)
Elizabeth M. C. Hillman, Univ. College London (United Kingdom)
Martin Schweiger, Univ. College London (United Kingdom)
Simon Robert Arridge, Univ. College London (United Kingdom)
David T. Delpy, Univ. College London (United Kingdom)

Published in SPIE Proceedings Vol. 4250:
Optical Tomography and Spectroscopy of Tissue IV
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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