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Proceedings Paper

Multichannel optical mapping: investigation of depth information
Author(s): Ichiro Sase; Hideo Eda; Akitoshi Seiyama; Hiroki C. Tanabe; Akira Takatsuki; Toshio Yanagida
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Paper Abstract

Near infrared (NIR) light has become a powerful tool for non-invasive imaging of human brain activity. Many systems have been developed to capture the changes in regional brain blood flow and hemoglobin oxygenation, which occur in the human cortex in response to neural activity. We have developed a multi-channel reflectance imaging system, which can be used as a `mapping device' and also as a `multi-channel spectrophotometer'. In the present study, we visualized changes in the hemodynamics of the human occipital region in multiple ways. (1) Stimulating left and right primary visual cortex independently by showing sector shaped checkerboards sequentially over the contralateral visual field, resulted in corresponding changes in the hemodynamics observed by `mapping' measurement. (2) Simultaneous measurement of functional-MRI and NIR (changes in total hemoglobin) during visual stimulation showed good spatial and temporal correlation with each other. (3) Placing multiple channels densely over the occipital region demonstrated spatial patterns more precisely, and depth information was also acquired by placing each pair of illumination and detection fibers at various distances. These results indicate that optical method can provide data for 3D analysis of human brain functions.

Paper Details

Date Published: 29 June 2001
PDF: 8 pages
Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); doi: 10.1117/12.434499
Show Author Affiliations
Ichiro Sase, Kansai Advanced Research Ctr. (Japan)
Hideo Eda, Kansai Advanced Research Ctr. (Japan)
Akitoshi Seiyama, Kansai Advanced Research Ctr. and Osaka Univ. Graduate School of Medicine (Japan)
Hiroki C. Tanabe, Kansai Advanced Research Ctr. (Japan)
Akira Takatsuki, Osaka Univ. Graduate School of Medicine (Japan)
Toshio Yanagida, Kansai Advanced Research Ctr. and Osaka Univ. Graduate School of Medicine (Japan)

Published in SPIE Proceedings Vol. 4250:
Optical Tomography and Spectroscopy of Tissue IV
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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