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Proceedings Paper

Experimental comparison of using continuous-wave and frequency-domain diffuse optical imaging systems to detect heterogeneities
Author(s): Quan Zhang; Thomas J. Brukilacchio; Thomas Gaudett; Lai Wang; Ang Li; David A. Boas
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Paper Abstract

Continuous-Wave (CW) and Frequency-Domain (RF) methods of diffuse optical imaging are compared to identify the optimal approach for a clinical system. The CW Imager features fast imaging with 9 frequency-encoded sources and 16 detectors. The homodyne RF imager has 40 sources modulated at a frequency of 70 MHz and 9 detectors. Both systems incorporate two wavelengths. The features and characterization of both system are discussed and compared. A versatile phantom box design is presented that offered flexibility in experimental design and facilitated optimization of probe geometry. A 3D absorption image reconstruction phantom experiment is carried out to test the performance of the RF system. Noise models are set up and experimentally verified, and a signal-to-noise ratio analysis is presented. The heterogeneity detection sensitivity of the CW method and the RF method are compared, using both simulation and phantom experiments. The comparison results are discussed in the context of the most suitable approach to the design of a clinical breast cancer detection system.

Paper Details

Date Published: 29 June 2001
PDF: 20 pages
Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); doi: 10.1117/12.434493
Show Author Affiliations
Quan Zhang, Massachusetts General Hospital/Harvard Medical School (United States)
Thomas J. Brukilacchio, Tufts Univ. (United States)
Thomas Gaudett, Massachusetts General Hospital/Harvard Medical School (United States)
Lai Wang, Tufts Univ. (United States)
Ang Li, Tufts Univ. (United States)
David A. Boas, Massachusetts General Hospital/Harvard Medical School and Tufts Univ. (United States)

Published in SPIE Proceedings Vol. 4250:
Optical Tomography and Spectroscopy of Tissue IV
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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