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Proceedings Paper

Functional imaging of muscle oxygenation using a 200-channel cw NIRS system
Author(s): Katsuyuki Yamamoto; Masatsugu Niwayama; Daisuke Kohata; Nobuki Kudo; Takatumi Hamaoka; Ryotaro Kime; Toshihito Katsumura
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Paper Abstract

Functional imaging of muscle oxygenation using NIRS is a promising technique for evaluation of the heterogeneity of muscle function and diagnosis of peripheral vascular disease or muscle injury. We have developed a 200-channel imaging system that can measure the changes in oxygenation and blood volume of muscles and that covers wider area than previously reported systems. Our system consisted of 40 probes, a multiplexer for switching signals to and from the probes, and a personal computer for obtaining images. In each probe, one two-wavelength LED (770 and 830 nm) and five photodiodes were mounted on a flexible substrate. In order to eliminate the influence of a subcutaneous fat layer, a correction method, which we previously developed, was also used in imaging. Thus, quantitative changes in concentrations of oxy- and deoxy-hemoglobin were obtained. Temporal resolution was 1.5 s and spatial resolution was about 20 mm, depending on probe separations. Exercise tests (isometric contraction of 50% MVC) on the thigh with and without arterial occlusion were conducted, and changes in muscle oxygenation were imaged using the developed system. Results showed that the heterogeneity of deoxygenation and reoxygenation during exercise and recovery periods, respectively, were clearly observed. These results suggest that optical imaging of dynamic change in muscle oxygenation using NIRS would be useful not only for basic physiological studies but also for clinical applications with respect to muscle functions.

Paper Details

Date Published: 29 June 2001
PDF: 11 pages
Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); doi: 10.1117/12.434486
Show Author Affiliations
Katsuyuki Yamamoto, Hokkaido Univ. (Japan)
Masatsugu Niwayama, Hokkaido Univ. (Japan)
Daisuke Kohata, Hokkaido Univ. (Japan)
Nobuki Kudo, Hokkaido Univ. (Japan)
Takatumi Hamaoka, Tokyo Medical College (Japan)
Ryotaro Kime, Tokyo Medical College (Japan)
Toshihito Katsumura, Tokyo Medical College (Japan)

Published in SPIE Proceedings Vol. 4250:
Optical Tomography and Spectroscopy of Tissue IV
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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