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Proceedings Paper

Temperature dependence of optical properties of in-vivo human skin
Author(s): Shu-Jen Yeh; Omar S. Khalil; Charles F. Hanna; Stan Kantor; Xiaomao Wu; Tzyy-Wen Jeng; Rene Alexander Bolt
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Paper Abstract

We examined the effect of temperature change on the diffuse reflectance of the skin. The optical probe consists of several optical fibers located at the center of a thermal electric device, which controls the temperature at the surface of the skin in contact. Measured light reflectance profile between 0.4-1.9 mm was fitted to a mathematical model obtained by Monte Carlo simulation, and absorption and scattering coefficients were estimated. The reduced scattering coefficient of the forearms consistently showed a positive relationship with temperature between 22 and 42 degree(s)C. This dependency was reversible without apparent delay. The same effect was observed on ex vivo pigskin. It is possible to explain the positive instantaneous dependency of scattering on temperature by the change of the refractive index of intercellular fluid. The scattering coefficient of the subcutaneous fat of pigskin showed a negative dependence on temperature. This negative dependency of scattering can be attributed to a phase change as a function of temperature. The absorption coefficient in vivo also increased with temperature from 22 to 42 degree(s)C. But the change was not immediately reversible after temperature reached 40 degree(s)C. This relationship was similar to the nonlinear increase in blood perfusion observed in laser Doppler measurements.

Paper Details

Date Published: 29 June 2001
PDF: 7 pages
Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); doi: 10.1117/12.434482
Show Author Affiliations
Shu-Jen Yeh, Abbott Labs. (United States)
Omar S. Khalil, Abbott Labs. (United States)
Charles F. Hanna, Abbott Labs. (United States)
Stan Kantor, Abbott Labs. (United States)
Xiaomao Wu, Abbott Labs. (United States)
Tzyy-Wen Jeng, Abbott Labs. (United States)
Rene Alexander Bolt, Univ. of Twente (Netherlands)

Published in SPIE Proceedings Vol. 4250:
Optical Tomography and Spectroscopy of Tissue IV
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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