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Proceedings Paper

Brain tissue charcterization using spectral imaging: a potential clinical tool
Author(s): Anita Mahadevan-Jansen; David Mongin; E. Duco Jansen; Dawn Pedrotty; Wei-Chiang Lin
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Paper Abstract

Spectral imaging as a modality combines two powerful techniques of imaging and fluorescence spectroscopy. By generating a 2-D image of an object with fluorescence information at every pixel, spectral imaging has the potential to provide clinicians with a valuable tool which can not only diagnosis the tissue but also provide an image of the boundary of where the normal and cancerous tissue intersect. The system used in these experiments was a modified spectral imaging system from Applied Spectral Imaging (SD-200, Carlsbad, CA). The system was mounted in an off-microscope configuration so that instead of performing microscopic measurements of tissue, macroscopic measurements on the order of several millimeters in size were collected. Preliminary results indicate that the spectra acquired from human brain tissues in vitro at individual pixels of the spectral image cube appear similar to that acquired using the single pixel system. Based on the findings of this study, spectral imaging has the potential to be a useful tool for tissue diagnostics and is currently limited by the speed of data acquisition and size of the data.

Paper Details

Date Published: 2 July 2001
PDF: 7 pages
Proc. SPIE 4259, Biomarkers and Biological Spectral Imaging, (2 July 2001); doi: 10.1117/12.432484
Show Author Affiliations
Anita Mahadevan-Jansen, Vanderbilt Univ. (United States)
David Mongin, Vanderbilt Univ. (United States)
E. Duco Jansen, Vanderbilt Univ. (United States)
Dawn Pedrotty, Vanderbilt Univ. (United States)
Wei-Chiang Lin, Vanderbilt Univ. (United States)

Published in SPIE Proceedings Vol. 4259:
Biomarkers and Biological Spectral Imaging
Gregory H. Bearman; Darryl J. Bornhop; Darryl J. Bornhop; Richard M. Levenson, Editor(s)

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