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Proceedings Paper

Initial development of a computer-aided diagnosis tool for solitary pulmonary nodules
Author(s): David Mark Catarious Jr.; Alan H. Baydush; Carey E. Floyd Jr.
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Paper Abstract

This paper describes the development of a computer-aided diagnosis (CAD) tool for solitary pulmonary nodules. This CAD tool is built upon physically meaningful features that were selected because of their relevance to shape and texture. These features included a modified version of the Hotelling statistic (HS), a channelized HS, three measures of fractal properties, two measures of spicularity, and three manually measured shape features. These features were measured from a difficult database consisting of 237 regions of interest (ROIs) extracted from digitized chest radiographs. The center of each 256x256 pixel ROI contained a suspicious lesion which was sent to follow-up by a radiologist and whose nature was later clinically determined. Linear discriminant analysis (LDA) was used to search the feature space via sequential forward search using percentage correct as the performance metric. An optimized feature subset, selected for the highest accuracy, was then fed into a three layer artificial neural network (ANN). The ANN's performance was assessed by receiver operating characteristic (ROC) analysis. A leave-one-out testing/training methodology was employed for the ROC analysis. The performance of this system is competitive with that of three radiologists on the same database.

Paper Details

Date Published: 3 July 2001
PDF: 8 pages
Proc. SPIE 4322, Medical Imaging 2001: Image Processing, (3 July 2001); doi: 10.1117/12.431148
Show Author Affiliations
David Mark Catarious Jr., Duke Univ. (United States)
Alan H. Baydush, Duke Univ. Medical Ctr. and Duke Univ. (United States)
Carey E. Floyd Jr., Duke Univ. Medical Ctr. and Duke Univ. (United States)

Published in SPIE Proceedings Vol. 4322:
Medical Imaging 2001: Image Processing
Milan Sonka; Kenneth M. Hanson, Editor(s)

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