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Proceedings Paper

2D line-scan photoacoustic imaging of absorbers in a scattering tissue phantom
Author(s): Paul C. Beard; Timothy N. Mills
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Paper Abstract

A photoacoustic imaging system has been evaluated by mapping the temporal distribution of photoacoustic signals generated in a tissue phantom. The phantom comprised an Intralipid scattering solution (μs'=1mm-1 and μa=0.01mm-1) containing two regions of enhanced absorption; a 1.5mm thick layer (μa=1mm-1) and a 75μm layer (μa=40mm-1). These were located 1cm beneath the surface of the Intralipid which was irradiated with 7ns Q switched laser pulses of fluence 0.05 J/cm2. A Fabry Perot polymer film ultrasound sensing interferometer was used for the detection of the photoacoustic signals. A 1D ultrasound array was simulated by illuminating the sensing interferometer with a large diameter laser beam and line scanning a photodiode across the reflected output beam. The detection sensitivity of the system was 3kPA over a 25MHz measurement bandwidth, the 3dB acoustic bandwidth was 17.5MHz, the sensitive azimuthal 'array' aperture and element size were 12mm and 0.8mm respectively. Greyscale images of the time-resolved photoacoustic signals enabled both absorbers to be clearly identified with an axial spatial resolution of less than 100micrometers . It is envisaged that this approach could form the basis of a practical photoacoustic tissue imaging system.

Paper Details

Date Published: 15 June 2001
PDF: 9 pages
Proc. SPIE 4256, Biomedical Optoacoustics II, (15 June 2001); doi: 10.1117/12.429319
Show Author Affiliations
Paul C. Beard, Univ. College London (United Kingdom)
Timothy N. Mills, Univ. College London (United Kingdom)

Published in SPIE Proceedings Vol. 4256:
Biomedical Optoacoustics II
Alexander A. Oraevsky, Editor(s)

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