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Proceedings Paper

Optimization of real-time high-frequency ultrasound for blood flow imaging in the microcirculation
Author(s): Dustin Edward Kruse; Jerome J. Mai; Ronald H. Silverman; Michael F. Insana; D. Jackson Coleman M.D.; Katherine W. Ferrara
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Paper Abstract

The first high frequency ultrasound system able to image blood flow in the microcirculation in real-time has been developed. 2D color flow frames are rapidly acquired using a recently reported method to achieve frame rates approaching 10 fps. A new flow phantom was constructed in order to tune the wall filter order, cutoff and attenuation for a 25 MHz, f/2 transducer. RF data were acquired in both M-mode and swept-mode, and processed in order to tune the wall filter. These filters were then used in making controlled measurements of flow velocity and volume flow rate for a typical PRF of 500 Hz (1 mm/sec scan speed). Over th einput of mean axial velocities ranging from 0.3 to 3.0 mm/sec (0.88 to 8.8 mm/sec angle corrected), the measured mean and maximum flow velocities were linear, with slight over-estimation of mean velocities due to the wall filter cutoff. Without correction for finite beam size, the volume flow rates were over-estimated by a factor of 2. The color flow settings were then applied to image microcirculatory flow within the nail bed of a human finger, where they were tested and optimized for a variety of vessel sizes and flow velocities.

Paper Details

Date Published: 30 May 2001
PDF: 9 pages
Proc. SPIE 4325, Medical Imaging 2001: Ultrasonic Imaging and Signal Processing, (30 May 2001); doi: 10.1117/12.428203
Show Author Affiliations
Dustin Edward Kruse, Univ. of California/Davis (United States)
Jerome J. Mai, Univ. of California/Davis (United States)
Ronald H. Silverman, Weill Medical College of Cornell Univ. (United States)
Michael F. Insana, Univ. of California/Davis (United States)
D. Jackson Coleman M.D., Weill Medical College of Cornell Univ. (United States)
Katherine W. Ferrara, Univ. of California/Davis (United States)

Published in SPIE Proceedings Vol. 4325:
Medical Imaging 2001: Ultrasonic Imaging and Signal Processing
Michael F. Insana; K. Kirk Shung, Editor(s)

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