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Proceedings Paper

Comparison of near-infrared spectroscopy with CT cerebral blood flow measurements in newborn piglets
Author(s): Derek W. Brown; Paul A. Picot; Roger Springett; David T. Delpy; Ting-Yim Lee
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Paper Abstract

Severely premature infants are often at high risk of cerebral hemorrhage or ischemic injury due to their inability to properly regulate blood flow to the brain. If blood flow is too high, the infant is at risk of cerebral hemorrhage, while too little blood flow can result in ischemic injury. The purpose of this research is to design and develop a means of non-invasively measuring cerebral blood flow (CBF) with near infrared spectroscopy (NIRS). Such a device would greatly aid the diagnosis and monitoring of afflicted infants. Previous attempts to measure CBF with NIRS have achieved limited success. In this study we acquired high signal-to-noise NIR spectrum from 600 to 980 nm with a cooled CCD spectrometer. This spectrometer enables the differential path length factor (DPF) to be estimated with accuracy using a second derivative technique described by Matcher et al. The validity of our new approach is determined via direct comparison with a previously validated computed tomography (CT) method. Three newborn piglets were studied. CBF measurements were performed at various partial arterial CO2 tensions (PaCO2) using both the NIRS and CT methods. The results of the two methods correlate well with a relationship of CBFCT equals -4.30 + 1.05 CBFNIRS (r2 equals 0.96).

Paper Details

Date Published: 21 May 2001
PDF: 9 pages
Proc. SPIE 4321, Medical Imaging 2001: Physiology and Function from Multidimensional Images, (21 May 2001); doi: 10.1117/12.428134
Show Author Affiliations
Derek W. Brown, St. Joseph's Health Ctr., London Health Science Ctr. and Univ. of Western Ontario (Canada)
Paul A. Picot, St. Joseph's Health Ctr. (Canada)
Roger Springett, Univ. College London (United States)
David T. Delpy, Univ. College London (United Kingdom)
Ting-Yim Lee, St. Joseph's Health Ctr., London Health Science Ctr., and Univ. of Western Ontario (Canada)

Published in SPIE Proceedings Vol. 4321:
Medical Imaging 2001: Physiology and Function from Multidimensional Images
Chin-Tu Chen; Anne V. Clough, Editor(s)

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