After several years of levodopa treatment, patients with Parkinson's Disease (PD) can develop difficult-to-control motor fluctuations and levodopa-induced dyskinesias (LID). Surgical options for these medically intractable PD patients include deep nucleus lesioning and stimulation. Because it is adjustable and reversible, deep brain stimulations (DBS) is preferable to ablative procedures. Traditionally, frame- based stereotaxy has been used to register these patients during deep electrode implantation. This study investigated the accuracy of the less invasive frameless registration method in 9 patients and found an overall mean error of 1.9mm (range: 1.1mm min, 2.7mm max) with an overall SD of 0.7mm. This error range is not acceptable for the submillimeter precision needed in microelectrode implantation. The lab is currently investing the accuracy of the frameless bone-screw marker method that is still less invasive and cumbersome than the frame-based system.

Date Published: 28 May 2001
PDF: 5 pages
Proc. SPIE 4319, Medical Imaging 2001: Visualization, Display, and Image-Guided Procedures, (28 May 2001); doi: 10.1117/12.428093

Published in SPIE Proceedings Vol. 4319:
Medical Imaging 2001: Visualization, Display, and Image-Guided Procedures
Seong Ki Mun, Editor(s)