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Proceedings Paper

Two-photon process takes aim at diagnosis and therapy of cancer
Author(s): Qirong Xing; Heying Wei; Lu Chai; Weili Zhang; Ning Zhang; Ching-yue Wang; Xuhong Miao; Yingxin Li
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Paper Abstract

We present a new method of diagnosing cancer, femtosecond laser in vivo HpD (haematoporphyrin derivatives) two-photon fluorescence, and observations of in vivo HpD two-photon fluorescence of cancer tissue of little mice using excitation of femtosecond laser pulse generated by self-mode-locked Ti:sapphire laser. The narrow pulse width, the high peak power of the excitation source and the central wavelength of 810 nm that is the window wavelength of biological tissue show that biomedical signal induced by this light source must have high signal-noise ratio. This femtosecond laser pulse and the two-photon fluorescence technique do no harm to normal tissue surrounding the cancer. The result of our experiments shows that the cancer tissue can be distinguished and diagnosed with the method of in vivo HpD two-photon fluorescence excited by femtosecond laser pulses with suitable wavelength.

Paper Details

Date Published: 29 May 2001
PDF: 5 pages
Proc. SPIE 4276, Commercial and Biomedical Applications of Ultrashort Pulse Lasers; Laser Plasma Generation and Diagnostics, (29 May 2001); doi: 10.1117/12.428014
Show Author Affiliations
Qirong Xing, Tianjin Univ. (China)
Heying Wei, Tianjin Univ. (China)
Lu Chai, Tianjin Univ. (China)
Weili Zhang, Tianjin Univ. (China)
Ning Zhang, Tianjin Univ. (China)
Ching-yue Wang, Tianjin Univ. (China)
Xuhong Miao, Tianjin Medical Univ. (China)
Yingxin Li, Tianjin Medical Univ. (China)


Published in SPIE Proceedings Vol. 4276:
Commercial and Biomedical Applications of Ultrashort Pulse Lasers; Laser Plasma Generation and Diagnostics
Richard F. Haglund Jr.; Richard F. Haglund Jr.; Richard F. Wood; Joseph Neev; Richard F. Wood, Editor(s)

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