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Proceedings Paper

Semiconductor microcavity laser spectroscopy of intracellular protein in human cancer cells
Author(s): Paul Lee Gourley; Jimmy D. Cox; Judy Kay Hendricks; Anthony E. McDonald; G. C. Copeland; Darryl Y. Sasaki; Mark S. Curry; Steven K. Skirboll
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Paper Abstract

The speed of light through a biofluid or biological cell is inversely related to the biomolecular concentration of proteins and other complex molecules comprising carbon- oxygen double bonds that modify the refractive index at wavelengths accessible to semiconductor lasers. By placing a fluid or cell into a semiconductor microcavity laser, these decreases in light speed can be sensitively recorded in picoseconds as frequency red-shifts in the laser output spectrum. This biocavity laser equipped with microfluidics for transporting cells at high speed through the laser microcavity has shown potential for rapid analysis of biomolecular mass of normal and malignant human cells in their physiologic condition without time-consuming fixing, staining, or tagging.

Paper Details

Date Published: 21 May 2001
PDF: 12 pages
Proc. SPIE 4265, Biomedical Instrumentation Based on Micro- and Nanotechnology, (21 May 2001); doi: 10.1117/12.427967
Show Author Affiliations
Paul Lee Gourley, Sandia National Labs. (United States)
Jimmy D. Cox, Sandia National Labs. (United States)
Judy Kay Hendricks, Sandia National Labs. (United States)
Anthony E. McDonald, Sandia National Labs. (United States)
G. C. Copeland, Sandia National Labs. (United States)
Darryl Y. Sasaki, Sandia National Labs. (United States)
Mark S. Curry, Univ. of New Mexico School of Medicine (United States)
Steven K. Skirboll, Univ. of New Mexico School of Medicine (United States)

Published in SPIE Proceedings Vol. 4265:
Biomedical Instrumentation Based on Micro- and Nanotechnology
Raymond P. Mariella Jr.; Dan V. Nicolau, Editor(s)

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