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Proceedings Paper

Glial cell adhesion and protein adsorption on SAM coated semiconductor and glass surfaces of a microfluidic structure
Author(s): Darryl Y. Sasaki; Jimmy D. Cox; Susan C. Follstaedt; Mark S. Curry; Steven K. Skirboll; Paul Lee Gourley
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Paper Abstract

The development of microsystems that merge biological materials with microfabricated structures is highly dependent on the successful interfacial interactions between these innately incompatible materials. Surface passivation of semiconductor and glass surfaces with thin organic films can attenuate the adhesion of proteins and cells that lead to biofilm formation and biofouling of fluidic structures. We have examined the adhesion of glial cells and serum albumin proteins to microfabricated glass and semiconductor surfaces coated with self-assembled monolayers of octadecyltrimethoxysilane and N-(triethoxysilylpropyl)-O- polyethylene oxide urethane, to evaluate the biocompatibility and surface passivation those coatings provide.

Paper Details

Date Published: 21 May 2001
PDF: 12 pages
Proc. SPIE 4265, Biomedical Instrumentation Based on Micro- and Nanotechnology, (21 May 2001); doi: 10.1117/12.427966
Show Author Affiliations
Darryl Y. Sasaki, Sandia National Labs. (United States)
Jimmy D. Cox, Sandia National Labs. (United States)
Susan C. Follstaedt, Sandia National Labs. (United States)
Mark S. Curry, Univ. of New Mexico School of Medicine (United States)
Steven K. Skirboll, Univ. of New Mexico School of Medicine (United States)
Paul Lee Gourley, Sandia National Labs. (United States)

Published in SPIE Proceedings Vol. 4265:
Biomedical Instrumentation Based on Micro- and Nanotechnology
Raymond P. Mariella Jr.; Dan V. Nicolau, Editor(s)

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