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Proceedings Paper

Bone microstructure deformation observed by Raman microscopy
Author(s): Michael D. Morris; Angela Carden; Rupak M. Rajachar; David H. Kohn
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Paper Abstract

While many macroscopic approaches have been used to study bone's mechanical properties, little is known about the effect of mechanical stresses on bone tissue at the microstructural and submicrostructural levels. Raman microspectroscopy has been found to be an extremely sensitive technique for examining the effects of mechanical loading on polymer structures and thin films, as well as for the study of protein conformations. We present the first application of this technique to bone tissue. The organic component of bone is a highly ordered matrix composed mainly of collagen fibrils. Stress upon the bone tissue creates disorder in this structure; this disorder can easily be detected by Raman spectroscopy. Small changes in the matrix structure manifest themselves as band shifts in the Raman spectra.

Paper Details

Date Published: 4 June 2001
PDF: 9 pages
Proc. SPIE 4254, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III, (4 June 2001); doi: 10.1117/12.427949
Show Author Affiliations
Michael D. Morris, Univ. of Michigan (United States)
Angela Carden, Univ. of Michigan (United States)
Rupak M. Rajachar, Univ. of Michigan (United States)
David H. Kohn, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 4254:
Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III
Tuan Vo-Dinh; Warren S. Grundfest M.D.; David A. Benaron M.D., Editor(s)

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