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Proceedings Paper

Disease pattern recognition in FT-IR spectra of human sera
Author(s): Wolfgang H. Petrich; Brion Dolenko; Daniel J. Fink; Johanna Frueh; Helmut Greger; Stephan Jacob; Franz Keller; Alexander Nikulin; Matthias Otto; Melissa S. Pessin-Minsley; Ortrud Quarder; Raymond L. Somorjai; Arnulf Staib; Ulrich Thienel; Gerhard H. Werner; Hans Wielinger
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Paper Abstract

We observed differences between the mid-infrared spectra of sera originating from healthy volunteers and from patients with diabetes mellitus or rheumatoid arthritis. These differences were found to be significant in terms of the Fisher criterion, the t-test, and the Kolmogorov-Smirnov test. The significance allows for a classification of the spectra and a probability (`DPR-score') of belonging to the class `healthy' can be computed. In comparing the samples from 80 diabetes patients with samples from 40 healthy volunteers we are able to achieve a sensitivity and a specificity of 80% and above. The DPR-score correlates better with the actual status of health than the glucose concentration alone. In a study on rheumatoid arthritis we compared the spectral signatures of sera taken from 188 rheumatoid arthritis patients and sera from 196 healthy volunteers. By applying linear discriminant analysis to 2/3 of the samples we are able to classify the remaining third of the samples (independent validation) with a sensitivity of 84% and a specificity of 88%.

Paper Details

Date Published: 4 June 2001
PDF: 9 pages
Proc. SPIE 4254, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III, (4 June 2001); doi: 10.1117/12.427948
Show Author Affiliations
Wolfgang H. Petrich, Roche Diagnostics GmbH (Germany)
Brion Dolenko, National Research Council Canada (Germany)
Daniel J. Fink, Columbia Univ. (Germany)
Johanna Frueh, Roche Diagnostics GmbH (Germany)
Helmut Greger, Medizinische Universitatsklinik Wuerzburg (Germany)
Stephan Jacob, Eberhard-Karls-Univ. Tuebingen (Germany)
Franz Keller, Medizinische Universitatsklinik Wuerzburg (Germany)
Alexander Nikulin, National Research Council Canada (Canada)
Matthias Otto, Freiberg Univ. of Mining and Technology (Germany)
Melissa S. Pessin-Minsley, Columbia Univ. (United States)
Ortrud Quarder, Roche Diagnostics GmbH (Germany)
Raymond L. Somorjai, National Research Council Canada (Canada)
Arnulf Staib, Roche Diagnostics GmbH (Germany)
Ulrich Thienel, New York Presbyterian Hospital (United States)
Gerhard H. Werner, Roche Diagnostics GmbH (Germany)
Hans Wielinger, Roche Diagnostics GmbH (Germany)

Published in SPIE Proceedings Vol. 4254:
Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III
Tuan Vo-Dinh; Warren S. Grundfest M.D.; David A. Benaron M.D., Editor(s)

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