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Proceedings Paper

Development and use of a confocal microendoscope for in-vivo histopathologic diagnosis
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Paper Abstract

A confocal microendoscope for in vivo imaging at the cellular level has been developed. The system consists of a slit-scanning confocal microscope coupled to a fiber optic imaging bundle with a miniature objective lens and focusing mechanism at the distal tip of the catheter. The system is used primarily for imaging tissue fluorescence--either autofluorescence or fluorescence from an exogenous compound. The microendoscope has a lateral resolution of 2 micrometers allowing visualization of structures at the cellular level, and because it is confocal, it can image at selected depths below the tissue surface. Excellent in vivo imaging results have been obtained in animal models and encouraging ex vivo results have been achieved with human tissue.

Paper Details

Date Published: 4 June 2001
PDF: 8 pages
Proc. SPIE 4254, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III, (4 June 2001); doi: 10.1117/12.427944
Show Author Affiliations
Arthur F. Gmitro, Optical Sciences Ctr./Univ. of Arizona (United States)
Andrew R. Rouse, Optical Sciences Ctr./Univ. of Arizona (United States)

Published in SPIE Proceedings Vol. 4254:
Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III
Tuan Vo-Dinh; Warren S. Grundfest M.D.; David A. Benaron M.D., Editor(s)

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