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Proceedings Paper

Development of an endoscopic fluorescence image-guided OCT probe for oral cancer detection
Author(s): Roger J. McNichols; Ashok Gowda; Brent A. Bell; Richard M. Johnigan; Karen H. Calhoun; Massoud Motamedi
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Paper Abstract

Oral squamous cell carcinoma is a disease which progresses through a number of well-defined morphological and biochemical changes. Optical coherence tomography (OCT) is a rapidly-evolving, non-invasive imaging modality which allows detailed probing of subsurface tissue structures with resolution on the order of microns. While this technique offers tremendous potential as a diagnostic tool for detection and characterization of oral cancer, OCT imaging is presently associated with a field of view on the order of millimeters, and acquisition time on the order of seconds. Thus, OCT's utility as a rapid cancer screening technique is presently limited. On the other hand, imaging of tissue autofluorescence provides a very rapid, high-throughput method for cancer screening. However, while autofluorescence measures may be sensitive to cancer, they are often non- specific and lead to a large number of false positives. In the present work, we have developed a fluorescence image guided optical coherence tomographic (FIG-OCT) probe in which tissue autofluorescence images are simultaneously used to guide OCT image acquisition of suspicious regions in real time. We have begun pre-clinical pilot studies with this instrument in a DMBA-induced model of oral cancer in the hamster cheek pouch. Initial results indicate that the FIG- OCT approach shows promise as a rapid and effective tool for screening of oral cancer.

Paper Details

Date Published: 4 June 2001
PDF: 8 pages
Proc. SPIE 4254, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III, (4 June 2001); doi: 10.1117/12.427941
Show Author Affiliations
Roger J. McNichols, BioTex, Inc. (United States)
Ashok Gowda, BioTex, Inc. (United States)
Brent A. Bell, Univ. of Texas Medical Branch at Galveston (United States)
Richard M. Johnigan, Univ. of Texas Medical Branch at Galveston (United States)
Karen H. Calhoun, Univ. of Texas Medical Branch at Galveston (United States)
Massoud Motamedi, Univ. of Texas Medical Branch at Galveston (United States)

Published in SPIE Proceedings Vol. 4254:
Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III
Tuan Vo-Dinh; Warren S. Grundfest M.D.; David A. Benaron M.D., Editor(s)

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