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Proceedings Paper

Evaluation of a new range of light-activated surgical adhesives for tissue repair in a porcine model
Author(s): Jill N. Riley; Diane E. Hodges; Keith L. March; Karen M. McNally-Heintzelman
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Paper Abstract

An in vitro study was conducted to determine the feasibility of using a new range of light-activated surgical adhesives for incision repair in a wide range of tissue types. Biodegradable polymer membranes of controlled porosity were fabricated with poly(L-lactic-co-glycolic acid) (PLGA) and salt particles using a solvent-casting and particulate- leaching technique. The porous membranes were doped with protein solder composed of 50%(w/v) bovine serum albumin solder and 0.5 mg/ml indocyanine green (ICG) dye mixed in deionized water. Tissue incisions were repaired using the surgical adhesive in conjunction with an 805-nm diode laser. Nine organs were tested ranging from skin to liver to the small intestine, as well as the coronary, pulmonary, carotid, femoral and splenetic arteries. Acute breaking strengths were measured and the data were analyzed by Student's T-test. Repairs formed on the small intestine were most successful followed by spleen, atrium, kidney, muscle and skin. The strongest vascular repairs were achieved in the carotid artery and femoral artery. The new surgical adhesive could possibly be used as a simple and effective method to stop bleeding and repair tissue quickly in an emergency situation, or as a substitute to mechanical staples or sutures in many clinical applications.

Paper Details

Date Published: 21 May 2001
PDF: 6 pages
Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001); doi: 10.1117/12.427795
Show Author Affiliations
Jill N. Riley, Rose-Hulman Institute of Technology (United States)
Diane E. Hodges, Univ. of Texas at Austin (United States)
Keith L. March, Indiana Univ. School of Medicine (United States)
Karen M. McNally-Heintzelman, Rose-Hulman Institute of Technology (United States)

Published in SPIE Proceedings Vol. 4244:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI
Lawrence S. Bass M.D.; David S. Robinson M.D.; Eugene A. Trowers M.D.; Kenton W. Gregory M.D.; Lou Reinisch; Kenneth Eugene Bartels D.V.M.; R. Rox Anderson M.D.; Reza S. Malek M.D.; Kenneth Eugene Bartels D.V.M.; Lloyd P. Tate V.D.M.; Abraham Katzir; C. Gaelyn Garrett M.D.; Timothy A. Woodward M.D.; Hans-Dieter Reidenbach; George M. Peavy D.V.M.; Lawrence S. Bass M.D.; C. Gaelyn Garrett M.D.; Michael D. Lucroy D.V.M.; Kenton W. Gregory M.D.; Abraham Katzir; Nikiforos Kollias; Michael D. Lucroy D.V.M.; Reza S. Malek M.D.; J. Stuart Nelson M.D.; George M. Peavy D.V.M.; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson M.D.; Lloyd P. Tate V.D.M.; Eugene A. Trowers M.D.; Timothy A. Woodward M.D., Editor(s)

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