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Proceedings Paper

Combined photoultrasonic treatment of infected wounds
Author(s): Vladimir P. Zharov; Yulian A. Menyaev; Konstantin L. Kalinin; Gregory N. Zmievskoy; Leonid Z. Velsher; Alexander A. Podkolzin; Mikhail L. Stakhanov; Yury Y. Gorchak; V. P. Sarantsev
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Paper Abstract

A new combined photoultrasonic (CPUS) technology for the treatment of infected wounds is suggested. The CPUS principal operation is based on the topical application of a photosensitizer followed by light irradiation in combination with low frequency ultrasonic (US) treatment of wounds. In CPUS, two methods - photodynamic (PDT) and ultrasonic therapies supplement each other beneficially and in conjunction provide a significant effect of deep suppurative inflammatory wounds treatment. The main advantages of the new technology are the combined application of an antibiotic solution and photodynamic therapy to destroy antibiotic- resistant microorganisms, an effective mixing of a photosensitizer in the wound, the US enhancement of photosensitizer impregnation into the membranes of bacteria, the US clearing of wound surface from necrotic products, an increased effective light dose exposure in the whole volume of the deep wound when the light does not penetrate totally inside the wound, an additional bactericidal effect under the US impact, and the combined effect of CPUS activation of the immune system.

Paper Details

Date Published: 21 May 2001
PDF: 10 pages
Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001); doi: 10.1117/12.427780
Show Author Affiliations
Vladimir P. Zharov, Bauman Moscow State Technical Univ. (United States)
Yulian A. Menyaev, Bauman Moscow State Technical Univ. (Russia)
Konstantin L. Kalinin, Bauman Moscow State Technical Univ. (Russia)
Gregory N. Zmievskoy, Bauman Moscow State Technical Univ. (Russia)
Leonid Z. Velsher, Moscow State Univ. of Medicine and Dentistry (Russia)
Alexander A. Podkolzin, Moscow State Univ. of Medicine and Dentistry (Russia)
Mikhail L. Stakhanov, Moscow State Univ. of Medicine and Dentistry (Russia)
Yury Y. Gorchak, Moscow State Univ. of Medicine and Dentistry (Russia)
V. P. Sarantsev, Moscow Scientific Production Association TELAS (Russia)

Published in SPIE Proceedings Vol. 4244:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI
Lawrence S. Bass M.D.; David S. Robinson M.D.; Eugene A. Trowers M.D.; Kenton W. Gregory M.D.; Lou Reinisch; Kenneth Eugene Bartels D.V.M.; R. Rox Anderson M.D.; Reza S. Malek M.D.; Kenneth Eugene Bartels D.V.M.; Lloyd P. Tate V.D.M.; Abraham Katzir; C. Gaelyn Garrett M.D.; Timothy A. Woodward M.D.; Hans-Dieter Reidenbach; George M. Peavy D.V.M.; Lawrence S. Bass M.D.; C. Gaelyn Garrett M.D.; Michael D. Lucroy D.V.M.; Kenton W. Gregory M.D.; Abraham Katzir; Nikiforos Kollias; Michael D. Lucroy D.V.M.; Reza S. Malek M.D.; J. Stuart Nelson M.D.; George M. Peavy D.V.M.; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson M.D.; Lloyd P. Tate V.D.M.; Eugene A. Trowers M.D.; Timothy A. Woodward M.D., Editor(s)

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