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Proceedings Paper

Cyclopeptide derivatives for molecular recognition
Author(s): Birgit Kiesser; Dirk Nopper; Martin Herold; Guenter Gauglitz; Martin Elbs; Stefan Groeschel; Roland Brock; Guenter Jung
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Paper Abstract

Cyclohexapeptides were bound covalently to interference and gold layer and tested for recognition of amino acids in liquid phase. The peptides consist of three L -amino acids as variable building block. Attachment to the surface took place by reaction of the amino group in the side chain of L-cysteine. Reflectometric Interferance Spectroscopy (RIfS) was used for the determination of the interaction of aminoacids. Surface Plasmon Resonance (SPR) was used for validation and additional measurement with small peptides .Cyclopeptides with different side chains demonstrated distinct recognition pattern for different amino acids. The interaction was fast and reversible.

Paper Details

Date Published: 26 February 2001
PDF: 9 pages
Proc. SPIE 4205, Advanced Environmental and Chemical Sensing Technology, (26 February 2001); doi: 10.1117/12.417434
Show Author Affiliations
Birgit Kiesser, Univ. of Tuebingen (Germany)
Dirk Nopper, Univ. of Tuebingen (Germany)
Martin Herold, Univ. of Tuebingen (Germany)
Guenter Gauglitz, Univ. of Tuebingen (Germany)
Martin Elbs, Univ. of Tuebingen (Germany)
Stefan Groeschel, Univ. of Tuebingen (Germany)
Roland Brock, Univ. of Tuebingen (Germany)
Guenter Jung, Univ. of Tuebingen (Germany)

Published in SPIE Proceedings Vol. 4205:
Advanced Environmental and Chemical Sensing Technology
Tuan Vo-Dinh; Stephanus Buettgenbach, Editor(s)

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