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Proceedings Paper

Phototoxic properties of dibiotinylated aluminum sulphophthalocyanine in vitro and in vivo
Author(s): Irina G. Meerovich; Victoria V. Zherdeva; Eugeny A. Lukianets; Valentina M. Derkacheva; Georgy N. Vorozhtsov; Gennadii A. Meerovich; Eugenia A. Kogan; Alexander P. Savitsky
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Paper Abstract

The investigations of photodynamic activity of the dibiotinylated aluminium sulphophthalocyanine in vitro and in vivo were performed. The results obtained showed that in vitro dibiotinylated aluminium sulphophthalocyanine provides an effective damage of small cell lung carcinoma OAT-75. In vivo dibiotinylated aluminium sulphophthalocyanine induces a total damage of Erlich carcinoma with expressed vascular damage even in a concentration 0.5 mg/kg of body weight.

Paper Details

Date Published: 31 January 2001
PDF: 7 pages
Proc. SPIE 4156, Clinical Lasers and Diagnostics, (31 January 2001); doi: 10.1117/12.413716
Show Author Affiliations
Irina G. Meerovich, Institute of Biochemistry (Russia)
Victoria V. Zherdeva, Institute of Biochemistry (Russia)
Eugeny A. Lukianets, Niopik Organic Intermediates and Dye Institute (Russia)
Valentina M. Derkacheva, Niopik Organic Intermediates and Dye Institute (Russia)
Georgy N. Vorozhtsov, Niopik Organic Intermediates and Dye Institute (Russia)
Gennadii A. Meerovich, General Physics Institute (Russia)
Eugenia A. Kogan, Moscow Medical Academy (Russia)
Alexander P. Savitsky, Institute of Biochemistry (Russia)

Published in SPIE Proceedings Vol. 4156:
Clinical Lasers and Diagnostics
Patrick Brouwer, Editor(s)

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