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Proceedings Paper

Application of 5-ALA for differential diagnostics of stomach diseases
Author(s): Natalja L. Okhotnikova; Sergey A. Dadvany; Michail I. Kuszin; Sergey S. Kharnas; Victor Ya. Zavodnov; Olga A. Sklyanskaya; Victor B. Loschenov; Anna I. Volkova; Valery V. Agafonov
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Paper Abstract

59 patients with stomach diseases including gastric cancer or polyp, gastritis, esofagus disease were investigated. Before gastroscopy all patients were given 5-ALA in doses 5mg, 10mg and 20mg per 1kg of body weight orally. Fluorescence diagnostics which estimates concentration of ALA-induced PPIX in regular and alternated tissues of gastric mucosa were carried out in 2-4 hours. Using of 5-ALA has shown high diagnostic effectiveness for differential diagnostics of stomach diseases. This technique has proved 10 diagnosis of cancer and revealed 15 malignant stomach diseases including 4 cancer in situ for patients with preliminary diagnosis of gastric ulcer. It also revealed 5 patients with enhanced fluorescence for which aimed biopsy has shown high degree of inflammation process. The latter were assigned as a risk group.

Paper Details

Date Published: 31 January 2001
PDF: 6 pages
Proc. SPIE 4156, Clinical Lasers and Diagnostics, (31 January 2001); doi: 10.1117/12.413712
Show Author Affiliations
Natalja L. Okhotnikova, Moscow Medical Academy (Russia)
Sergey A. Dadvany, Moscow Medical Academy (Russia)
Michail I. Kuszin, Moscow Medical Academy (Russia)
Sergey S. Kharnas, Moscow Medical Academy (Russia)
Victor Ya. Zavodnov, Moscow Medical Academy (Russia)
Olga A. Sklyanskaya, Moscow Medical Academy (Russia)
Victor B. Loschenov, General Physics Institute (Russia)
Anna I. Volkova, General Physics Institute (Russia)
Valery V. Agafonov, General Physics Institute (Russia)

Published in SPIE Proceedings Vol. 4156:
Clinical Lasers and Diagnostics
Patrick Brouwer, Editor(s)

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