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Proceedings Paper

Interferometric optical fiber microcantilever beam biosensor
Author(s): Thomas A. Wavering; Scott A. Meller; Mishell K. Evans; Charles Pennington; Mark E. Jones; Roger VanTassell; Kent A. Murphy; William H. Velander; E. Valdes
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Paper Abstract

With the proliferation of biological weapons, the outbreak of food poisoning occurrences, and the spread of antibiotic resistant strains of pathogenic bacteria, the demand has arisen for portable systems capable of rapid, specific, and quantitative target detection. The ability to detect minute quantities of targets will provide the means to quickly assess a health hazardous situation so that the appropriate response can be orchestrated. Conventional test results generally require hours or even several days to be reported, and there is no change for real-time feedback. An interferometric optical fiber microcantilever beam biosensor has successfully demonstrated real time detection of target molecules. The microcantilever biosensor effectively combines advanced technology from silicon micromachining, optical fiber sensor, and biochemistry to create a novel detection device. This approach utilizes affinity coatings on micromachiend cantilever beams to attract target molecules. The presence of the target molecule causes bending in the cantilever beam, which is monitored using an optical displacement system. Dose-response trials have shown measured responses at nanogram/ml concentrations of target molecules. Sensitivity is expected to extend from the nanogram to the picogram range of total captured mass as the microcantilever sensors are optimized.

Paper Details

Date Published: 29 December 2000
PDF: 7 pages
Proc. SPIE 4200, Biochemical and Biomolecular Sensing, (29 December 2000); doi: 10.1117/12.411717
Show Author Affiliations
Thomas A. Wavering, Luna Innovations, Inc. (United States)
Scott A. Meller, Luna Innovations, Inc. (United States)
Mishell K. Evans, Luna Innovations, Inc. (United States)
Charles Pennington, Luna Innovations, Inc. (United States)
Mark E. Jones, Luna Innovations, Inc. (United States)
Roger VanTassell, Luna Innovations, Inc. (United States)
Kent A. Murphy, Luna Innovations, Inc. (United States)
William H. Velander, Virginia Polytechnic Institute and State Univ. (United States)
E. Valdes, U.S. Army Edgewood Research, Development, and Engineering Ctr. (United States)

Published in SPIE Proceedings Vol. 4200:
Biochemical and Biomolecular Sensing
Robert A. Lieberman, Editor(s)

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