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Proceedings Paper

Three-tiered fluorescence-based system for monitoring activation-related changes in human platelets
Author(s): Alexander M. Christov; William J. Kostuk; George Jablonsky; Paulette Desjardins; Ruth Courtis; Bernice Jardine; Anne Bailey; June Odlum-Blair; Janice Motiejunas; Sheila McConnell; Alexandra Lucas
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Paper Abstract

A method for simultaneous fluorescence spectroscopic measurement of surface membrane fluidity, platelet aggregation, and intracellular calcium concentration was developed. The capacity of the system to assess platelet activation associated with coronary artery angioplasty and anti-platelet treatment was confirmed. This approach offers a new analytical technique for circulating platelet activation.

Paper Details

Date Published: 16 November 2000
PDF: 13 pages
Proc. SPIE 4161, Optical Biopsy and Tissue Optics, (16 November 2000); doi: 10.1117/12.409327
Show Author Affiliations
Alexander M. Christov, Univ. of Western Ontario (United States)
William J. Kostuk, London Health Science Ctr. (Canada)
George Jablonsky, London Health Science Ctr. (Canada)
Paulette Desjardins, London Health Science Ctr. (Canada)
Ruth Courtis, London Health Science Ctr. (Canada)
Bernice Jardine, London Health Science Ctr. (Canada)
Anne Bailey, London Health Science Ctr. (Canada)
June Odlum-Blair, London Health Science Ctr. (Canada)
Janice Motiejunas, London Health Science Ctr. (Canada)
Sheila McConnell, London Health Science Ctr. (Canada)
Alexandra Lucas, Univ. of Western Ontario (Canada)

Published in SPIE Proceedings Vol. 4161:
Optical Biopsy and Tissue Optics
Irving J. Bigio; Gerhard J. Mueller; Gerwin J. Puppels; Rudolf W. Steiner; Katarina Svanberg M.D., Editor(s)

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