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Proceedings Paper

Low-power protein crystallography using polycapillary optics
Author(s): Huapeng Huang; Carolyn A. MacDonald; Walter M. Gibson; D. C. Carter; J. X. Ho; J. R. Ruble; Igor Yu. Ponomarev
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Paper Abstract

This paper describes the design and performance of a low power protein crystallography system using polycapillary optics. The characterization of the source and polycapillary optics are presented. Three optic types: collimating, slightly focusing and strongly focusing optics have been used in low power source-optic combination systems. The source-collimating optic and source- slightly focusing optic systems were used to collect data sets for chicken egg-white Lysozyme with conventional sample oscillation during data collection. The data sets show high quality by analysis with a conventional software package, DENZO. Still diffraction patterns without oscillation have also been obtained by a low power source-strongly focusing optic combination. These patterns have been analyzed by developing software for processing diffraction patterns obtained with strongly convergent X-ray beams. The directions of future work and system improvements are also discussed.

Paper Details

Date Published: 2 November 2000
PDF: 10 pages
Proc. SPIE 4144, Advances in Laboratory-based X-Ray Sources and Optics, (2 November 2000); doi: 10.1117/12.405885
Show Author Affiliations
Huapeng Huang, SUNY/Albany (United States)
Carolyn A. MacDonald, SUNY/Albany (United States)
Walter M. Gibson, SUNY/Albany (United States)
D. C. Carter, New Century Pharmaceuticals Inc. (United States)
J. X. Ho, New Century Pharmaceuticals Inc. (United States)
J. R. Ruble, New Century Pharmaceuticals Inc. (United States)
Igor Yu. Ponomarev, X-Ray Optical Systems, Inc. (United States)

Published in SPIE Proceedings Vol. 4144:
Advances in Laboratory-based X-Ray Sources and Optics
Carolyn A. MacDonald; Ali M. Khounsary, Editor(s)

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