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Proceedings Paper

Sonoluminescence imaging and its biomedical applications
Author(s): Da Xing; Yonghong He; Yonghong Tang; Shici Tan
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Paper Abstract

Sonoluminescence (SL) images of living bodies were obtained by a luminescence enhancement method with a high-sensitive back-illuminated CCD system. We found that the rare-gas- contained (prepared) PBS or some nonpoisonous chemiluminescent analytic agent could enhance the SL by chemiluminescence through a reaction with free radicals, and can be used for in vivo experiments. Based on ultrasound could sensitize HpD to produce the oxygen free radicals, a novel method for early-stage cancer diagnosis named as Sono- Dynamic Diagnosis was proposed. By use of sonosensitization to produce tumor-selective oxygen radicals, a clear diagnostic image of FCLA (Fluoresceinyl Cypridina Luminescent Analog)-enhanced sono-pumped chemiluminescence from tumor region is obtained. Finally, a confocal scanning technique was developed for the sonoluminescence tomography imaging for the first time. The spatial resolution was largely improved to about 100 micro with the ultrasonic intensity less than the safety limit of FDA. With the components-labeling and confocal techniques, the SL imaging method has potential applications in clinical diagnosis.

Paper Details

Date Published: 11 October 2000
PDF: 5 pages
Proc. SPIE 4224, Biomedical Photonics and Optoelectronic Imaging, (11 October 2000); doi: 10.1117/12.403972
Show Author Affiliations
Da Xing, South China Normal Univ. (China)
Yonghong He, South China Normal Univ. (China)
Yonghong Tang, South China Normal Univ. (China)
Shici Tan, South China Normal Univ. (China)

Published in SPIE Proceedings Vol. 4224:
Biomedical Photonics and Optoelectronic Imaging
Hong Liu; Qingming Luo, Editor(s)

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