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Proceedings Paper

Functions of laser light, laser-absorbing dye, and immunoadjuvants in photodynamic immunotherapy
Author(s): Wei R. Chen; Hong Liu; Kenneth Eugene Bartels D.V.M.; Robert E. Nordquist
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Paper Abstract

Photo Dynamic Immuno Therapy (PDIT) is a novel approach for treatment of metastatic tumors. It involves an intratumor administration of a laser-absorbing dye and an immunoadjuvant, followed by a non-invasive laser irradiation. Previous studies using a novel immunoadjuvant, glycated chitosan, showed the effect of the treatment on a metastatic breast tumor in rats, including the eradication of treated primary tumors, regression of untreated metastases, and the evidence of immune responses induced by the treatment. To further understand the mechanism of PDIT, tumor-bearing rats were treated by different combinations of the three PDIT components. The rat survival rates and profiles of primary and metastatic tumors, after treatment by individual component and different combinations of components, were analyzed. All the experimental groups without using immunoadjuvant showed none or little positive effect. The use of glycated chitosan, either by itself or in combination of other components, has showed that among the concentrations of 0.5%, 1% and 2%, glycated chitosan was most effective at 1% in PDIT. Another immunoadjuvant, incomplete Freund's adjuvant, was also used and the results were compared with that of using glycated chitosan. PDIT was applied to a different tumor model- Met-Lu, a prostatic tumor with lung metastases in male rats and the preliminary results are reported.

Paper Details

Date Published: 11 October 2000
PDF: 9 pages
Proc. SPIE 4224, Biomedical Photonics and Optoelectronic Imaging, (11 October 2000); doi: 10.1117/12.403939
Show Author Affiliations
Wei R. Chen, Univ. of Central Oklahoma and Univ. of Oklahoma (United States)
Hong Liu, Johns Hopkins Univ. (United States)
Kenneth Eugene Bartels D.V.M., Oklahoma State Univ. (United States)
Robert E. Nordquist, Univ. of Oklahoma and Wound Healing of Oklahoma, Inc. (United States)

Published in SPIE Proceedings Vol. 4224:
Biomedical Photonics and Optoelectronic Imaging
Hong Liu; Qingming Luo, Editor(s)

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