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Proceedings Paper

Inverting dedevelopment: geometric singularity theory in embryology
Author(s): Fred L. Bookstein; Bradley R. Smith
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Paper Abstract

The diffeomorphism model so useful in the biomathematics of normal morphological variability and disease is inappropriate for applications in embryogenesis, where whole coordinate patches are created out of single points. For this application we need a suitable algebra for the creation of something from nothing in a carefully organized geometry: a formalism for parameterizing discrete nondifferentiabilities of invertible functions on Rk, k $GTR 1. One easy way to begin is via the inverse of the development map - call it the dedevelopment map, the deformation backwards in time. Extrapolated, this map will inevitably have singularities at which its derivative is zero. When the dedevelopment map is inverted to face forward in time, the singularities become appropriately isolated infinities of derivative. We have recently introduced growth visualizations via extrapolations to the isolated singularities at which only one directional derivative is zero. Maps inverse to these create new coordinate patches directionally rather than radically. The most generic singularity that suits this purpose is the crease f(x,y) equals (x,x2y+y3), which has already been applied in morphometrics for the description of focal morphogenetic phenomena. We apply it to embryogenesis in the form of its analytic inverse, and demonstrate its power using a priceless new data set of mouse embryos imaged in 3D by micro-MR with voxels smaller than 100micrometers 3.

Paper Details

Date Published: 4 October 2000
PDF: 14 pages
Proc. SPIE 4121, Mathematical Modeling, Estimation, and Imaging, (4 October 2000); doi: 10.1117/12.402451
Show Author Affiliations
Fred L. Bookstein, Univ. of Michigan (United States)
Bradley R. Smith, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 4121:
Mathematical Modeling, Estimation, and Imaging
David C. Wilson; Hemant D. Tagare; Fred L. Bookstein; Francoise J. Preteux; Edward R. Dougherty, Editor(s)

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