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Proceedings Paper

Active microfluidic mixer for mixing of microparticles and liquids
Author(s): Jin-Woo Choi; Chong Hyuk Ahn
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Paper Abstract

This paper presents a new active microfluidic mixer for mixing of microparticles and liquid samples using electrohydrodynamic (EHD) convection for applications in microfluidic-based biochemical analysis systems and biochips. To understand the EHD convection mixing, analytical analysis on the micro mixer have been performed for two different liquid samples with different electric conductivities. Through the analytical simulation, a new active micro mixer for both liquid/liquid mixing and liquid/microparticles mixing has been designed, fabricated, and demonstrated for application of a magnetic microbead- based analysis system. Magnetic beads that are dispersed in buffer solution have been fully mixed with the selected liquid sample while passing the mixing zone, which has voltage of between 7 to 25 V applied across it. Since the realized micro mixer has simple structure and no mechanically moving parts, it shows very reliable and repeatable mixing performance. The active micro mixing device studied in this work also shows feasible mixing capabilities of microparticles in naon- or pico-liter range of liquid volumes by applying a low voltage of 7 V across the microchannel. Furthermore reliable, robust mixing and manipulating of microparticles in liquid samples can be rapidly achieved.

Paper Details

Date Published: 18 August 2000
PDF: 8 pages
Proc. SPIE 4177, Microfluidic Devices and Systems III, (18 August 2000); doi: 10.1117/12.395652
Show Author Affiliations
Jin-Woo Choi, Univ. of Cincinnati (United States)
Chong Hyuk Ahn, Univ. of Cincinnati (United States)

Published in SPIE Proceedings Vol. 4177:
Microfluidic Devices and Systems III
Carlos H. Mastrangelo; Holger Becker, Editor(s)

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