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Proceedings Paper

Passive adoptive transfer of antitumor immunity induced by laser-dye-immunoadjuvant treatment in a rat metastatic breast cancer model
Author(s): Wei R. Chen; Hong Liu; Anil K. Singhal; Robert E. Nordquist
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Paper Abstract

The ideal cancer treatment modalities should not only cause tumor regression and eradication but also induce a systemic anti-tumor immunity. This is essential for control of metastatic tumors and for long-term tumor resistance. Laser immunotherapy using a laser, a laser-absorbing dye and an immunoadjuvant has induced such a long-term immunity in treatment of a mammary metastatic tumor. The successfully treated rats established total resistance to multiple subsequent tumor challenges. For further mechanistic studies of the antitumor immunity induced by this novel treatment modality, passive adoptive transfer was performed using splenocytes as immune cells. The spleen cells harvested from successfully treated tumor-bearing rats provided 100% immunity in the naive recipients. The passively protected first cohort rats were immune to tumor challenge with an increased tumor dose; their splenocytes also prevented the establishment of tumor in the second cohort of naive recipient rats. This immunity transfer was accomplished without the usually required T-cell suppression in recipients.

Paper Details

Date Published: 13 June 2000
PDF: 7 pages
Proc. SPIE 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical, (13 June 2000); doi: 10.1117/12.388056
Show Author Affiliations
Wei R. Chen, Univ. of Central Oklahoma and Univ. of Oklahoma (United States)
Hong Liu, Johns Hopkins Univ. (United States)
Anil K. Singhal, Light Sciences (United States)
Robert E. Nordquist, Univ. of Oklahoma and Wound Healing of Oklahoma, Inc. (United States)

Published in SPIE Proceedings Vol. 3914:
Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical
Jeffrey O. Hollinger D.D.S.; Donald Dean Duncan; Jeffrey O. Hollinger D.D.S.; Donald Dean Duncan; Steven L. Jacques, Editor(s)

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