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Proceedings Paper

Free-electron laser effects on fibrin tissue glue: a preliminary study
Author(s): Karen Margaret Joos M.D.; Katie Topadze; Charles Shieh; Jin-Hui Shen; Vivien A. Casagrande
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Paper Abstract

One glaucoma challenge is the treatment of leaking trabeculectomy blebs. Simple methods such as patching, autologous blood injection, compression sutures or cyanoacrylate glue application often fail. Because the conjunctiva is thin and ischemic, it often can't be sutured together so major surgery is required to excise the thin tissue and advance healthy conjunctiva. We report the preliminary results of Tisseel and Tisseel treated with two wavelengths from Vanderbilt's free electron laser placed on leaking trabeculectomy bleb holes in Dutch belted rabbits. The holes were healed at one week in the sutured group and in the 7.7 micrometer FEL-treated Tisseel group. One hole was healed in the cyanoacrylate glue-treated group. Holes remained in the other treatment groups. Tisseel irradiated with 7.7 micrometer energy from the free electron laser may promote healing of trabeculectomy bleb holes.

Paper Details

Date Published: 7 June 2000
PDF: 6 pages
Proc. SPIE 3908, Ophthalmic Technologies X, (7 June 2000); doi: 10.1117/12.387516
Show Author Affiliations
Karen Margaret Joos M.D., Vanderbilt Univ. (United States)
Katie Topadze, Vanderbilt Univ. (United States)
Charles Shieh, Vanderbilt Univ. (United States)
Jin-Hui Shen, Vanderbilt Univ. (United States)
Vivien A. Casagrande, Vanderbilt Univ. (United States)

Published in SPIE Proceedings Vol. 3908:
Ophthalmic Technologies X
Pascal O. Rol; Karen Margaret Joos M.D.; Fabrice Manns, Editor(s)

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