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Proceedings Paper

Infrared microspectroscopy of benign and neoplastic prostate: correlation of spectral patterns with histopathology
Author(s): Luis Chiriboga; Max Diem; Herman Terence Yee
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Paper Abstract

The diagnosis of prostate cancer is based on the visible microscopic evaluation of both cytological and architectural features of the prostate tissue sections. In order to determine whether IR spectral 'mapping' can be used to objectively distinguish between normal and neoplastic prostate tissue, a comparison between 'visual, point-by- point' and 'automated, point-by-point' IR measurements was performed. Automated, point-by-point analysis was performed without any prior diagnostic information. Visual, point-by- point measurements were based on histopathology, histochemistry and immunohistochemical analysis of the tissue samples. The spectra obtained from these measurements were compared to the spectra obtained from automated point- by-point analysis. Our results indicate that the spectra obtained from histopathologically directed measurements compares well with those of automated mapping methods. Therefore, we believe that current mapping methodology can be directly correlated with pathological diagnoses.

Paper Details

Date Published: 8 May 2000
PDF: 8 pages
Proc. SPIE 3918, Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques, (8 May 2000); doi: 10.1117/12.384947
Show Author Affiliations
Luis Chiriboga, New York Univ. School of Medicine and Bellevue Hospital and CUNY/Hunter College (United States)
Max Diem, CUNY/Hunter College (United States)
Herman Terence Yee, New York Univ. School of Medicine and Bellevue Hospital (United States)

Published in SPIE Proceedings Vol. 3918:
Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques
Anita Mahadevan-Jansen; Gerwin J. Puppels, Editor(s)

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