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Proceedings Paper

Recognition of disease-specific patterns in FT-IR spectra of human sera
Author(s): Wolfgang H. Petrich; Brion Dolenko; Johanna Frueh; Helmut Greger; Stephan Jacob; Franz Keller; Alexander Nikulin; Matthias Otto; Ortrud Quarder; Raymond L. Somorjai; Arnulf Staib; Gerhard H. Werner; Hans Wielinger
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Paper Abstract

Vibrational spectra in the mid-IR region show significant and reproducible correlation with the disease state of the blood donor. When focusing our 'disease pattern recognition (DPR)' approach onto the example of diabetes mellitus we can clearly separate samples obtained from healthy volunteers from those samples which organized from diabetes patients. Furthermore, we are able to differentiate between samples of type-1 diabetics and type-2 diabetics. For disease pattern recognition we use linear and/or regularized discriminant analysis. In a binary, supervised classification of an pair of the three disease states: healthy, diabetes type-1 and diabetes type-2, we consistently achieve sensitivities and specificities >= 80 percent. By setting stricter bounds on the range of acceptable probabilities of belonging to a certain class, we obtain even higher values for the sensitivity and the specificity on the expense of the fraction of 'crisply' classified samples. Since we are able to simultaneously quantify the concentrations of biochemical serum components like glucose, cholesterol and triglycerides from the identical set of spectra with regression coefficients > 90 percent, our approach allows for a direct cross-link between the molecule-based and the disease-based interpretation of the spectra.

Paper Details

Date Published: 8 May 2000
PDF: 6 pages
Proc. SPIE 3918, Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques, (8 May 2000); doi: 10.1117/12.384942
Show Author Affiliations
Wolfgang H. Petrich, Roche Diagnostics GmbH (Germany)
Brion Dolenko, National Research Council Canada (Germany)
Johanna Frueh, Roche Diagnostics GmbH (Germany)
Helmut Greger, Medizinische Univ. Wurzburg (Germany)
Stephan Jacob, Univ. Tuebingen (Germany)
Franz Keller, Medizinische Univ. Wurzburg (Germany)
Alexander Nikulin, National Research Council Canada (Canada)
Matthias Otto, Technische Univ. Bergakademie Freiberg (Germany)
Ortrud Quarder, Roche Diagnostics GmbH (Germany)
Raymond L. Somorjai, National Research Council Canada (Canada)
Arnulf Staib, Roche Diagnostics GmbH (Germany)
Gerhard H. Werner, Roche Diagnostics GmbH (Germany)
Hans Wielinger, Roche Diagnostics GmbH (Germany)

Published in SPIE Proceedings Vol. 3918:
Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques
Anita Mahadevan-Jansen; Gerwin J. Puppels, Editor(s)

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