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Proceedings Paper

Surface-enhanced Raman spectroscopy for the near real-time diagnosis of brain trauma in rats
Author(s): D. Patrick O'Neal; Massoud Motamedi; Jefferson Chen M.D.; Gerard L. Cote
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Paper Abstract

The detection of sever brain trauma remains difficult when employing traditional methods in part due to the pathophysiological complexity of the condition. Current brain trauma detection includes schemes that require bulky, expensive equipment to deduce regional cerebral blood flow. These methods are difficult to use in conjunction with patients requiring ongoing intensive care and constant monitoring. Our previous studies have shown that surface- enhanced Raman spectroscopy (SERS) with silver colloids has the ability to measure physiological concentrations of in vivo brain analytes linked to brain trauma using short scan times. More recently, after implementing a damage model for ischemia in rats, an ex vivo analysis of brain microdialysis samples shows a correlation between SERS spectral features and the occurrence and location of known localized ischaemia. A near real-time measurement system could provide relevant clinical information in anticipation of surgical or pharmaceutical interventions for severely head injured patients.

Paper Details

Date Published: 8 May 2000
PDF: 6 pages
Proc. SPIE 3918, Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques, (8 May 2000); doi: 10.1117/12.384939
Show Author Affiliations
D. Patrick O'Neal, Texas A&M Univ. (United States)
Massoud Motamedi, Univ. of Texas Medical Branch at Galveston (United States)
Jefferson Chen M.D., Univ. of Texas Medical Branch at Galveston (United States)
Gerard L. Cote, Texas A&M Univ. (United States)

Published in SPIE Proceedings Vol. 3918:
Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques
Anita Mahadevan-Jansen; Gerwin J. Puppels, Editor(s)

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