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Proceedings Paper

Quantitative characterization of the progression of focal brain ischemia in a rat photochemical stroke model using in-vivo MRI
Author(s): Anne-Marie Van der Linden; Marleen Verhoye; M. De Ryck
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Paper Abstract

Stroke models, if used in drug evaluation studies, should have a predictable and reproducible course and outcome. While most drug trials focus on the lesion outcome, our study shows the importance of studying lesion growth instead of lesion outcome. In the study reported here, the time course of a photochemically induced neocortical infarct is studied in rats, using diffusion-weighted magnetic resonance imaging, while the rats were submitted to a rigorous control of physiological parameters, ensuring constant body temperature, blood gases (pO2 and pCO2), arterial pressure, heart rate and plasma glucose levels. Under such a stable physiological condition, rats were imaged as soon as possible after lesion up to 6 hours, which is the most important period to determine the slope of further lesion growth and final outcome. The data show that the initial size of the lesion is important for the further outcome of the stroke, both in lesion size and severity of the ischemic damage, as reflected by changes in the Apparent Diffusion Coefficient.

Paper Details

Date Published: 20 April 2000
PDF: 9 pages
Proc. SPIE 3978, Medical Imaging 2000: Physiology and Function from Multidimensional Images, (20 April 2000); doi: 10.1117/12.383430
Show Author Affiliations
Anne-Marie Van der Linden, Univ. Antwerp (Belgium)
Marleen Verhoye, Univ. Antwerp (Belgium)
M. De Ryck, Janssen Research Foundation (Belgium)

Published in SPIE Proceedings Vol. 3978:
Medical Imaging 2000: Physiology and Function from Multidimensional Images
Chin-Tu Chen; Anne V. Clough, Editor(s)

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