Share Email Print

Proceedings Paper

Automated three-dimensional spatial standardization and quantification of myocardial perfusion tomography: alternative to polar maps
Author(s): Piotr J. Slomka; Perry E. Radau; Gilbert Hurwitz; Damini Dey
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

We developed a novel clinical tool (PERFIT) for automated 3-D voxel-based quantification of myocardial perfusion, validated it with a wide spectrum of angiographically correlated cases, compared it to previous approaches, and tested its agreement with visual expert reading. A multistage, 3-D iterative inter- subject registration of patient images to normal stress and rest cardiac templates was applied, including automated masking of external activity before final fit. The reference templates were adjusted to the individual left ventricles by template erosion, for further shape correction. 125 angiographically correlated cases including multi-vessel disease, infarction, and dilated ventricles were tested. In addition, standard polar maps were generated automatically from the registered data. Results of consensus visual reading (V) and PERFIT (P) were compared. The iterative fitting was successful in 245/250 (99%) stress and rest images. PERFIT found defects on stress in 2/29 normal patients and 95/96 abnormal patients. Overall correlation between V and P findings was r equals 0.864. In all abnormal groups (n equals 96), PERFIT average defect sizes expressed as the percentage the myocardial volume were 9.6% for rest and 22.3% for stress, versus 11.4% (rest) and 23% (stress) for visual reading. Automatic quantification by PERFIT is consistent with visual analysis; it can be applied to the analysis whole spectrum of clinical images, and can aid physicians in interpretation of myocardial perfusion.

Paper Details

Date Published: 20 April 2000
PDF: 9 pages
Proc. SPIE 3978, Medical Imaging 2000: Physiology and Function from Multidimensional Images, (20 April 2000);
Show Author Affiliations
Piotr J. Slomka, London Health Sciences Ctr., Univ. of Western Ontario, and John P. Robarts Research Instit (Canada)
Perry E. Radau, London Health Sciences Ctr. and Univ. of Western Ontario (Canada)
Gilbert Hurwitz, London Health Sciences Ctr. (Canada)
Damini Dey, John P. Robarts Research Institute (Canada)

Published in SPIE Proceedings Vol. 3978:
Medical Imaging 2000: Physiology and Function from Multidimensional Images
Chin-Tu Chen; Anne V. Clough, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?