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Proceedings Paper

Blood flow changes resulting from laser heating measured using dynamic contrast-enhanced computed tomography
Author(s): Thomas G. Purdie; Michael D. Sherar; Aaron Fenster; Ting-Yim Lee
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Paper Abstract

The measurement of blood flow is important to understanding the physiological effects of heating on tissue. The primary effect of thermal therapies on solid tumors is the collapse of the blood vessels supplying the tumor, resulting in a thermal lesion due to the cessation of blood flow. We investigated the effect of heating on VX2 tumors implanted in the rabbit thigh, over the course of a one-hour treatment. A method of measuring the blood flow over an entire tissue slice using dynamic contrast-enhanced CT was developed. The distribution of the blood flow values was displayed as a single image in which a spectrum of pseudo-colors was used to encode blood flow values. This blood flow map provides both a visual and quantitative means of assessing blood flow changes and hence the tissue damage over time. From the blood flow maps we defined thermal lesions as tissue regions which had blood flow in the range of 0 - 2 ml/min/100g. Using this definition, the ratio of the thermal lesion area from pre-treatment to 60 minutes post-treatment, increased by a factor of 6, whereas the same ratios for the normal and viable tumor tissue remained essentially constant.

Paper Details

Date Published: 20 April 2000
PDF: 10 pages
Proc. SPIE 3978, Medical Imaging 2000: Physiology and Function from Multidimensional Images, (20 April 2000); doi: 10.1117/12.383421
Show Author Affiliations
Thomas G. Purdie, Univ. of Western Ontario and John P. Robarts Research Institute (Canada)
Michael D. Sherar, Ontario Cancer Institute and Univ. of Toronto (Canada)
Aaron Fenster, Univ. of Western Ontario and John P. Robarts Research Institute (Canada)
Ting-Yim Lee, Univ. of Western Ontario, John P. Robarts Research Institute, and St. Joseph's Health Ctr. (Canada)

Published in SPIE Proceedings Vol. 3978:
Medical Imaging 2000: Physiology and Function from Multidimensional Images
Chin-Tu Chen; Anne V. Clough, Editor(s)

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