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Proceedings Paper

Accurate estimation of contrast agent dynamics in fast contrast-enhanced MRI
Author(s): Henkjan J. Huisman; J. O. Barentsz
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Paper Abstract

Contrast enhanced MRI (CE-MRI) is increasingly being used for tumor characterization as well as therapy response monitoring. We are investigating the diagnostic value of fast, multi-slice [1.5X1.5X5(mm)] CE-MRI with a time interval of 2(s) to enables estimating perfusion parameters. A clinical visualization tool is being developed that estimates curve parameters on a per voxel basis to be able to analyze the heterogeneous tumor physiology. MRI image noise strongly affects the (perfusion) related start-of-enhancement and time- to-peak estimates especially in low contrast curves. We therefore developed a robust estimation method. It was tested on realistic simulations and in vivo CE-MRI data and compared to existing methods. The new method is shown to be more accurate, precise and robust than common least-squares optimization based methods.

Paper Details

Date Published: 20 April 2000
PDF: 9 pages
Proc. SPIE 3978, Medical Imaging 2000: Physiology and Function from Multidimensional Images, (20 April 2000); doi: 10.1117/12.383415
Show Author Affiliations
Henkjan J. Huisman, Univ. Hospital Nijmegen (Netherlands)
J. O. Barentsz, Univ. Hospital Nijmegen (Netherlands)

Published in SPIE Proceedings Vol. 3978:
Medical Imaging 2000: Physiology and Function from Multidimensional Images
Chin-Tu Chen; Anne V. Clough, Editor(s)

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