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Proceedings Paper

Physiological imaging of electrical trauma and therapeutic responses
Author(s): Chin-Tu Chen; K. Matthews; John Nathan Aarsvold; Robert A. Mintzer; Nicholas J. Yasillo; Jurgen Hannig; M. Capelli-Schellpfefer; Malcolm Cooper; Raphael C. Lee M.D.
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Paper Abstract

In victims of electrical trauma, electroporation of cell membrane, in which lipid bilayer is permeabilized by thermal and electrical forces, is thought to be a substantial cause of tissue damage. It has been suggested that certain mild surfactant in low concentration could induce sealing of permeabilized lipid bilayers, thus repairing cell membranes that had not been extensively damaged. With an animal model of electrically injured hind limb of rats, we have demonstrated and validated the use of radiotracer imaging technique to assess the physiology of the damaged tissues after electrical shock and of their repairs after applying surfactant as a therapeutic strategy. For example, using Tc-99m labeled pyrophosphate (PYP), which follows calcium in cellular function and is known to accumulate in damaged tissues, we have established a physiological imaging approach for assessment of the extent of tissue injury for diagnosis and surgical planning, as well as for evaluation of responses to therapy. With the use of a small, hand-held, miniature gamma camera, this physiological imaging method can be employed at patient's bedside and even in the field, for example, at accident site or during transfer for emergency care, rapid diagnosis, and prompt treatment in order to maximize the chance for tissue survival.

Paper Details

Date Published: 20 April 2000
PDF: 5 pages
Proc. SPIE 3978, Medical Imaging 2000: Physiology and Function from Multidimensional Images, (20 April 2000); doi: 10.1117/12.383414
Show Author Affiliations
Chin-Tu Chen, Univ. of Chicago (United States)
K. Matthews, Rush-Presbyterian-St. Luke's Medical Ctr. (United States)
John Nathan Aarsvold, Emory Univ. and Veterans Affairs Medical Ctr. (United States)
Robert A. Mintzer, Emory Univ. and Veterans Affairs Medical Ctr. (United States)
Nicholas J. Yasillo, Univ. of Chicago (United States)
Jurgen Hannig, Univ. of Chicago (United States)
M. Capelli-Schellpfefer, Univ. of Chicago (United States)
Malcolm Cooper, Univ. of Chicago (United States)
Raphael C. Lee M.D., Univ. of Chicago (United States)

Published in SPIE Proceedings Vol. 3978:
Medical Imaging 2000: Physiology and Function from Multidimensional Images
Chin-Tu Chen; Anne V. Clough, Editor(s)

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