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Proceedings Paper

Blue LEDs feasibility for tissue fluorescence analysis
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Paper Abstract

We considered the limited number of light-induced fluorescence applications for marketed ultra-bright blue LEDs where they can compete with versatile laser sources. Satisfactory optical output and miniature size as well as low power consumption of blue LEDs emitting at 470 nm allow to consider them as a promising alternatives to metal vapor or gas lasers used in many expires LIF applications. Available to authors LEDs form Hewlett-Packard, Micro Electronics Corp., Nichia Chemical Industries Ltd. and Toyoda Gosei Co. were tested to comply with demands to a tissue excitation source for portable spectroscopes. The optical performance of LEDs has shown that selected group of InGaN LEDs could be successfully used for that. The miniature illuminator that includes LED, focusing condenser, filter set and distal fiberoptic light concentrator was designed and tested in conjunction with portable CCD- equipped spectroscope. Operating in dark condition the proposed LED illuminator provides the level of fluorescence signal sufficient to detect spectral abnormalities in human Caucasian skin and excised gastrointestinal samples. All tissue autofluorescence data taken under LED illumination were compared with readings under He-Cd laser excitation and showed a good match. A new diagnostic designs based on LEDs were considered for clinical use.

Paper Details

Date Published: 19 April 2000
PDF: 9 pages
Proc. SPIE 3917, Optical Biopsy III, (19 April 2000); doi: 10.1117/12.382725
Show Author Affiliations
Sergiy M. Dets, National Technical Univ. of Ukraine and Simon Fraser Univ. (Canada)
Nikolay A. Denisov, National Technical Univ. of Ukraine (Ukraine)

Published in SPIE Proceedings Vol. 3917:
Optical Biopsy III
Robert R. Alfano, Editor(s)

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