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Proceedings Paper

Optical assessment of tissue mechanical properties
Author(s): Sean J. Kirkpatrick
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Paper Abstract

Many disease processes, such as scirrhous carcinoma of the breast and atherosclerosis physically manifest themselves as changes in the mechanical properties of the involved tissue. Optical evaluation of the mechanical properties of biological tissues offers methods that can directly provide information regarding the state of health of both hard and soft tissue. Clinically, this information may be used for diagnostic purposes. Since all biological tissues display viscoelastic behavior and therefore exhibits a time dependence of their mechanical behavior, the important quantities for evaluating the mechanics of tissue under load are those that reflect this time dependence. For example, by evaluating the retardation spectrum of the tissue, the underlying molecular processes that govern the mechanical behavior may be elucidated. Understanding these spectra may provide insight into pathological processes and also provide some guidance for the development of synthetic materials or engineered tissues to replace damaged or pathological tissue. Thus, there is a need for methods that directly assess the time rate of the mechanical response of tissue to an imposed load. Herein, a few such methods will be discussed and applications to biomaterials and medical diagnostics will be discussed.

Paper Details

Date Published: 6 April 2000
PDF: 10 pages
Proc. SPIE 4001, Saratov Fall Meeting '99: Optical Technologies in Biophysics and Medicine, (6 April 2000); doi: 10.1117/12.381478
Show Author Affiliations
Sean J. Kirkpatrick, Oregon Health Sciences Univ. (United States)

Published in SPIE Proceedings Vol. 4001:
Saratov Fall Meeting '99: Optical Technologies in Biophysics and Medicine
Valery V. Tuchin; Dmitry A. Zimnyakov; Alexander B. Pravdin, Editor(s)

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