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Proceedings Paper

Living chips for drug discovery
Author(s): Tanya S. Kanigan; Colin J. H. Brenan; Serge Lafontaine; Luke Sosnowski; Peter Geoffrey Madden; Ian Warwick Hunter
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Paper Abstract

We have developed novel microarray technology for performing large numbers (up to 106) of chemical and cell-based assays in parallel. This technology is particularly relevant to the high-throughput screening methods used by the pharmaceutical industry to identify potential drug candidates. In this paper we provide an overview of the system and its enabling technologies, including an economical manufacturing process for creating these microarrays, a fluorescence imaging system for detecting `hits', a fluid delivery system for loading arrays, and a method for mixing reagents.

Paper Details

Date Published: 22 March 2000
PDF: 9 pages
Proc. SPIE 3926, Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing, (22 March 2000);
Show Author Affiliations
Tanya S. Kanigan, Massachusetts Institute of Technology (United States)
Colin J. H. Brenan, Massachusetts Institute of Technology (United States)
Serge Lafontaine, Massachusetts Institute of Technology (United States)
Luke Sosnowski, Massachusetts Institute of Technology (United States)
Peter Geoffrey Madden, Massachusetts Institute of Technology (United States)
Ian Warwick Hunter, Massachusetts Institute of Technology (United States)


Published in SPIE Proceedings Vol. 3926:
Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing
Patrick A. Limbach; John C. Owicki; Ramesh Raghavachari; Weihong Tan, Editor(s)

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