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Proceedings Paper

BioMEMS applied to the development of cell-based bioassay systems
Author(s): Colin J. H. Brenan; Karel Domansky; Petra Kurzawski; Linda G. Griffith
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Paper Abstract

Biological applications of MEMS technology (bioMEMS) is of increasing interest in the development of miniature and portable instrumentation for cell-based microassays and sensor applications. A major bioMEMS challenge is the physical incorporation of living cells into sensors and diagnostic devices and creation of the environmental conditions conducive for organization of differentiated cells into tissue-like structures. Our work towards these goals is illustrated by a tissue-based bioassay system we are developing based on a miniature cross-flow bioreactor constructed from of an array of cell-filled microchannels integrated into an environmentally-controlled polymer microfluidics manifold. We describe our microchannel array and manifold manufacturing methods and report on the in vitro culture of cell populations in the bioreactor.

Paper Details

Date Published: 15 March 2000
PDF: 12 pages
Proc. SPIE 3912, Micro- and Nanotechnology for Biomedical and Environmental Applications, (15 March 2000); doi: 10.1117/12.379564
Show Author Affiliations
Colin J. H. Brenan, Massachusetts Institute of Technology (United States)
Karel Domansky, Massachusetts Institute of Technology (United States)
Petra Kurzawski, Massachusetts Institute of Technology (United States)
Linda G. Griffith, Massachusetts Institute of Technology (United States)


Published in SPIE Proceedings Vol. 3912:
Micro- and Nanotechnology for Biomedical and Environmental Applications
Raymond P. Mariella Jr., Editor(s)

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