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Proceedings Paper

Photodynamic effect of deuteroporphyrin IX derivatives on isolated nerve cell
Author(s): Anatoly B. Uzdensky; Andrei V. Ivanov; Andrei V. Reshetnickov; Gelii V. Ponomarev; Olga Yu. Dergacheva; Anna A. Zhavoronkova
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Paper Abstract

Deuteroporphyrin IX derivatives are prospective PDT porphyrin photosensitizers (PS). The photodynamic effects of 6 new amphiphilic deuteroporphyrin derivatives with different hydrophobicity, as well as effects of known photosensitizers Photoheme and Photosens (used for comparison) on the firing of isolated crayfish mechanoreceptor neuron have been studied. After 30 min photosensitization, neurons were irradiated with He-Ne laser (632.8 nm, 0.3 W/cm2), and changes in neuron firing frequency were recorded. It has been shown that neuron firing is very sensitive to photodynamic impact and can serve as a sensitive indicator of cell photodamage.

Paper Details

Date Published: 30 December 1999
PDF: 10 pages
Proc. SPIE 4059, Laser Use in Oncology II, (30 December 1999); doi: 10.1117/12.375258
Show Author Affiliations
Anatoly B. Uzdensky, Rostov State Univ. (Russia)
Andrei V. Ivanov, N.N. Blokhin Cancer Research Ctr. (Russia)
Andrei V. Reshetnickov, Institute of Biomedical Chemistry (Russia)
Gelii V. Ponomarev, Institute of Biomedical Chemistry (Russia)
Olga Yu. Dergacheva, Rostov State Univ. (Russia)
Anna A. Zhavoronkova, Rostov State Univ. (Russia)

Published in SPIE Proceedings Vol. 4059:
Laser Use in Oncology II
Andrei V. Ivanov; Mishik A. Kazaryan, Editor(s)

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