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Proceedings Paper

GARDobes: primordial cell nano-precursors with organic catalysis, compositional genome, and capacity to evolve
Author(s): Daniel Segre; Dafna Ben-Eli; Yitzhak Pilpel; Ora Kedem; Doron Lancet
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Paper Abstract

The Graded Autocatalysis Replication Domain (GARD) model described here depicts an early primordial scenario, prior to the emergence of biopolymers, such as RNA or proteins. The model describes, with the help of statistical chemistry computer simulations, a collection of organic molecular species capable of rudimentary selection and evolution. The GARD model provides a rigorous kinetic analysis of simple sets of chemicals that manifest mutual catalysis. It is shown that catalytic closure can sustain self replication up to a critical dilution rate, related to the extent of mutual catalysis. The capacity for self replication in a mutually catalytic set is shown to be a graded property, quantitated by a critical parameter (lambda) ci. GARD could be a simple model for a primordial scenario, in which replication and catalysis are performed by the same set of molecules.

Paper Details

Date Published: 30 December 1999
PDF: 19 pages
Proc. SPIE 3755, Instruments, Methods, and Missions for Astrobiology II, (30 December 1999); doi: 10.1117/12.375084
Show Author Affiliations
Daniel Segre, Weizmann Institute of Science (Israel)
Dafna Ben-Eli, Weizmann Institute of Science (Israel)
Yitzhak Pilpel, Weizmann Institute of Science (Israel)
Ora Kedem, Weizmann Institute of Science (Israel)
Doron Lancet, Weizmann Institute of Science (Israel)

Published in SPIE Proceedings Vol. 3755:
Instruments, Methods, and Missions for Astrobiology II
Richard B. Hoover, Editor(s)

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