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Proceedings Paper

Preliminary observations of breast tumor collagen using synchrotron radiation
Author(s): Robert A. Lewis; Keith D. Rogers; Christopher J. Hall; Elizabeth Towns-Andrews; Susan Slawson; Andrew Evans; Sarah E. Pinder; Ian O. Ellis; Caroline R. M. Boggis; Alan P. Hufton; David R. Dance
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Paper Abstract

The most frequently occurring cancer in women is that of the breast where it accounts for almost 20% of all cancer deaths. The U.K. has the world's highest mortality rate from breast cancer with an increasing incidence of 25000 per annum. Characterizing the complex physiological and tissue changes that form the natural history of breast cancer is clearly important for understanding associated biological mechanisms and for diagnosis. We report the initial findings of a diffraction study of breast tissue collagen that we believe may be due to tumor genesis. Small angle, synchrotron X-ray scattering has enabled us to examine `core cut' biopsy specimens and characterize their collagen architecture. We present data that demonstrates possible structural differences between tumor and normal tissue. We discuss the implications of these findings in the context of using molecular structure characteristics as new and novel markers of disease progression.

Paper Details

Date Published: 6 October 1999
PDF: 6 pages
Proc. SPIE 3770, Medical Applications of Penetrating Radiation, (6 October 1999); doi: 10.1117/12.368187
Show Author Affiliations
Robert A. Lewis, CLRC/Daresbury Lab. (United Kingdom)
Keith D. Rogers, Cranfield Univ. (United Kingdom)
Christopher J. Hall, CLRC/Daresbury Lab. (United Kingdom)
Elizabeth Towns-Andrews, CLRC/Daresbury Lab. (United Kingdom)
Susan Slawson, CLRC/Daresbury Lab. (United Kingdom)
Andrew Evans, City Hospital Nottingham (United Kingdom)
Sarah E. Pinder, City Hospital Nottingham (United Kingdom)
Ian O. Ellis, City Hospital Nottingham (United Kingdom)
Caroline R. M. Boggis, Nightingale Ctr./Withington Hospital (United Kingdom)
Alan P. Hufton, Christie Hospital (United Kingdom)
David R. Dance, Royal Marsden Hospital (United Kingdom)

Published in SPIE Proceedings Vol. 3770:
Medical Applications of Penetrating Radiation
H. Bradford Barber; Hans Roehrig, Editor(s)

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