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Proceedings Paper

Microbeam radiation therapy
Author(s): Jean A. Laissue; Nadia Lyubimova; Hans-Peter Wagner; David W. Archer; Daniel N. Slatkin M.D.; Marco Di Michiel; Christian Nemoz; Michel Renier; Elke Brauer; Per O. Spanne; Jan-Olef Gebbers; Keith Dixon; Hans Blattmann
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Paper Abstract

The central nervous system of vertebrates, even when immature, displays extraordinary resistance to damage by microscopically narrow, multiple, parallel, planar beams of x rays. Imminently lethal gliosarcomas in the brains of mature rats can be inhibited and ablated by such microbeams with little or no harm to mature brain tissues and neurological function. Potentially palliative, conventional wide-beam radiotherapy of malignant brain tumors in human infants under three years of age is so fraught with the danger of disrupting the functional maturation of immature brain tissues around the targeted tumor that it is implemented infrequently. Other kinds of therapy for such tumors are often inadequate. We suggest that microbeam radiation therapy (MRT) might help to alleviate the situation. Wiggler-generated synchrotron x-rays were first used for experimental microplanar beam (microbeam) radiation therapy (MRT) at Brookhaven National Laboratory's National Synchrotron Light Source in the early 1990s. We now describe the progress achieved in MRT research to date using immature and adult rats irradiated at the European Synchrotron Radiation Facility in Grenoble, France, and investigated thereafter at the Institute of Pathology of the University of Bern.

Paper Details

Date Published: 6 October 1999
PDF: 8 pages
Proc. SPIE 3770, Medical Applications of Penetrating Radiation, (6 October 1999); doi: 10.1117/12.368185
Show Author Affiliations
Jean A. Laissue, Univ. of Berne (Switzerland)
Nadia Lyubimova, Univ. of Berne (Switzerland)
Hans-Peter Wagner, Univ. of Berne (Switzerland)
David W. Archer, Univ. of Berne (Canada)
Daniel N. Slatkin M.D., Univ. of Berne (United States)
Marco Di Michiel, European Synchrotron Radiation Facility (France)
Christian Nemoz, European Synchrotron Radiation Facility (France)
Michel Renier, European Synchrotron Radiation Facility (France)
Elke Brauer, European Synchrotron Radiation Facility (France)
Per O. Spanne, European Synchrotron Radiation Facility (France)
Jan-Olef Gebbers, Cantonal Hospital (Switzerland)
Keith Dixon, Novartis Services AG (Switzerland)
Hans Blattmann, Paul Scherrer Institute (Switzerland)

Published in SPIE Proceedings Vol. 3770:
Medical Applications of Penetrating Radiation
H. Bradford Barber; Hans Roehrig, Editor(s)

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