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Proceedings Paper

Hyperspectral imaging for dermal hemoglobin spectroscopy
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Paper Abstract

It has been shown previously that images collected at selected wavelengths in a sufficiently narrow bandwidth can be used to produce maps of the oxygen saturation of hemoglobin in the dermis. A four-wavelength algorithm has been developed based on a two-layer model of the skin, in which the blood is contained in the lower layer (dermis), while the upper layer attenuates some of the reflection and adds a clutter term. In the present work, the algorithm is compared analytically to simpler algorithms using three wavelengths and based on a single-layer model. It is shown through Monte-Carlo models that, for typical skin, the single-layer model is adequate to analyze data from fiber-optical reflectance spectroscopy, but the two-layer model produces better results for imaging systems. Although the model does not address the full complexity of reflectance of a two-layer skin, it has proven to be sufficient to recover the oxygen saturation, and perhaps other medically relevant information. The algorithm is demonstrated on a suction blister, where the epidermis is removed to reveal the underlying dermis. Applications for this imaging modality exist in dermatology, in surgery, and in developing treatment plans for various diseases.

Paper Details

Date Published: 15 October 1999
PDF: 11 pages
Proc. SPIE 3752, Subsurface Sensors and Applications, (15 October 1999); doi: 10.1117/12.365686
Show Author Affiliations
Peter J. Dwyer, Massachusetts General Hospital (United States)
Charles A. DiMarzio, Northeastern Univ. (United States)

Published in SPIE Proceedings Vol. 3752:
Subsurface Sensors and Applications
Cam Nguyen, Editor(s)

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