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Proceedings Paper

Light-induced fluorescence endoscopy (LIFE) imaging system for early cancer detection
Author(s): Haishan Zeng; Calum E. MacAulay; Stephen Lam; Branko Palcic
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Paper Abstract

This paper summarizes our experiences on the development of a Light Induced Fluorescence Endoscopy (LIFE) imaging system for early cancer detection in the respiratory and gastrointestinal tract. The system utilizes tissue autofluorescence to provide real time video imaging of the examined organ. No exogenous fluorescent tumor markers are needed. It is used by a physician in adjunct to conventional white-light endoscopy. Suspicious areas are identified in pseudo color to guide biopsy. A multi- center clinical trial has demonstrated that in the lung, the relative sensitivity of white-light imaging + LIFE imaging vs. white-light imaging alone was 6.3 for intraepithelial neoplastic lesion detection and 2.71 when invasive carcinomas were also included. The following issues will be discussed: (1) spectroscopy study design for imaging system development; (2) architecture of the imaging systems; (3) different imaging modalities (white-light imaging, dual channel fluorescence imaging, and combined fluorescence/reflectance imaging); and (4) clinical applications.

Paper Details

Date Published: 17 September 1999
PDF: 8 pages
Proc. SPIE 3863, 1999 International Conference on Biomedical Optics, (17 September 1999); doi: 10.1117/12.364398
Show Author Affiliations
Haishan Zeng, British Columbia Cancer Agency (Canada)
Calum E. MacAulay, British Columbia Cancer Agency (Canada)
Stephen Lam, British Columbia Cancer Agency (Canada)
Branko Palcic, British Columbia Cancer Agency (Canada)

Published in SPIE Proceedings Vol. 3863:
1999 International Conference on Biomedical Optics
Qingming Luo; Britton Chance; Lihong V. Wang; Steven L. Jacques, Editor(s)

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